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Giovanni Battista Castagna, a seasoned diplomat and cardinal, ascended to the papacy as Urban VII on September 15, 1590, at the age of 69. His election was met with widespread joy, as he was known for his piety, learning, and opposition to nepotism. Despite his extensive experience in various ecclesiastical and administrative roles, including serving as Apostolic Nuncio to Spain and Venice, his reign as the head of the Catholic Church would be remarkably brief.
Tragically, just twelve days after his election, and before his coronation, Urban VII succumbed to malaria on September 27, 1590. Rome in the 16th century was particularly susceptible to malaria, a parasitic disease thriving in marshy areas like the Tiber River valley. The city's fluctuating population and uneven geography, interspersed with low-lying drainage zones, created ideal breeding grounds for mosquitoes. This "Roman fever," as it was sometimes called, was a significant health hazard, and the late 16th century marked a peak in its virulence, especially during the warmer months of August and September.
Even in his very short time as Pope, Urban VII demonstrated his commitment to reform and charity. He reportedly subsidized Roman bakers to provide affordable bread, restricted luxury spending for his court, and initiated public works projects. He also instituted the world's first known public smoking ban, threatening excommunication for anyone using tobacco in or near a church. His untimely death, therefore, cut short a papacy that promised significant positive changes, leaving behind a legacy of good intentions and a poignant reminder of the fragility of life and leadership in an era before modern medicine. His estate, valued at a considerable 30,000 scudi, was bequeathed to a confraternity to provide dowries for poor young girls.