In which Telemundo dramedy series do two best friends, Constanza Franco and Remedios Rivera, decide to take a 100-day break from their respective marriages to evaluate their happiness and relationships?

The Telemundo dramedy series in which best friends Constanza Franco and Remedios Rivera decide to take a 100-day break from their marriages to evaluate their happiness and relationships is titled 100 días para enamorarnos (Review) (English: "100 Days To Fall In Love"). The series, a Spanish-language American production by Telemundo Global Studios, premiered on April 28, 2020. It is an adaptation of an Argentine telenovela of the same name.

The plot centers on Constanza Franco, a sophisticated and successful lawyer, wife, and mother, and her best friend, Remedios Rivera, a loving wife and mother with a free-spirited and somewhat chaotic nature. Both women, after 20 years of marriage, find themselves questioning their relationships. Constanza proposes a 100-day "break" from her husband, Plutarco, to see if they can rekindle their love or if separation is the answer. Remedios, dealing with her own marital issues and the reappearance of a past love, eventually follows a similar path.

"100 días para enamorarnos" explores themes of love, marriage, friendship, and self-discovery, with a comedic and dramatic tone. The series delves into the complexities of modern relationships, including topics like inclusion, bullying, and gender diversity. It was filmed in Miami and ran for two seasons, comprising 92 episodes, concluding in 2021. The show received critical acclaim, including a Premios PRODU award for Best Telenovela in 2020.