Known for its host's self-deprecating humor and celebrity interviews, this late-night talk show aired on TBS from 2010 to 2021. What is the name of this TV show?

The television show described, known for its host's self-deprecating humor and celebrity interviews, which aired on TBS from 2010 to 2021, is indeed "Conan". Hosted by Conan O'Brien, the program was a staple of late-night television for over a decade, featuring his distinctive comedic style and engaging conversations with a wide array of guests.

Conan O'Brien's move to TBS in 2010 followed a highly publicized departure from NBC's "The Tonight Show." After a brief and tumultuous stint as host of that iconic program, O'Brien found a new home on cable, where he was able to cultivate a show that leaned into his unique brand of humor. This included his well-known self-deprecating jokes, a blend of the absurd and witty, and a spontaneous hosting style that often involved physical comedy and surreal sketches.

Initially an hour-long program, "Conan" evolved over its run, shifting to a 30-minute format in 2019 to focus more on comedy segments and less on the traditional desk-and-interview structure. The show also famously spawned the Emmy-winning "Conan Without Borders" travel specials, which showcased O'Brien's humor in international settings. The series concluded in June 2021, marking the end of O'Brien's nearly three-decade career in late-night television.