What long-running American late-night talk show, which premiered on January 26, 2003, features celebrity interviews, musical guests, and comedic sketches, hosted by its namesake comedian on ABC?

The long-running American late-night talk show that premiered on January 26, 2003, featuring celebrity interviews, musical guests, and comedic sketches, hosted by its namesake comedian on ABC, is "Jimmy Kimmel Live!". The show debuted following Super Bowl XXXVII, initially airing at 12:05 a.m. ET/PT before moving to its current 11:35 p.m. ET/PT slot in 2013. Jimmy Kimmel, known for his quick wit and "everyman" personality, created and hosts the nightly hour-long program.

Before becoming a late-night fixture, Jimmy Kimmel had a career in radio and gained national attention as the co-host of Comedy Central's "Win Ben Stein's Money," earning an Emmy Award in 1999. He also co-hosted "The Man Show," which helped establish his comedic credibility. When "Jimmy Kimmel Live!" first started, it faced the challenge of shedding Kimmel's previous "frat-boy image" and attracting guests, but its edgy content gradually garnered a significant following, particularly among younger viewers.

Over its more than two decades on air, "Jimmy Kimmel Live!" has become ABC's longest-running late-night talk show. The show is known for its engaging celebrity interviews, diverse musical performances, and popular recurring comedic segments. Fan-favorite bits include "Mean Tweets," where celebrities read humorous insults about themselves, and "Lie Witness News," which features man-on-the-street interviews about fabricated headlines. Kimmel has also used his platform to address important social issues, blending humor with thoughtful commentary.